5 minute read


5 minute read

CBD vs. THC – Important Differences

Cannabinoids are a group of naturally occurring chemical compounds in hemp plants. Of the 80+ known cannabinoids, two are important to highlight: Tetrahydrocannabinol (THC) and Cannabidiol (CBD).

THC and CBD are of special interest because each chemical has the potential to provide individuals with significant bodily effects. THC and CBD act on receptors found throughout the human body and brain. However, the effects of CBD and THC differ dramatically from each other. This guide will breakdown the major similarities and differences between the two chemicals.

woman waking up in the morning with cbd and coffee for a sense of calmness

CBD doesn’t get you high – THC does

Instead of getting you high, research shows CBD has the following effects:

  • Decreases social anxiety and relieves stress from a long day
  • Helps support movement and healthy joint functions
  • Reduce painful aches from over-exertion

Different Molecular Structure

Chemical structures of CBD & THC cannabinoids

The way individual molecules¹ are arranged in CBD and THC are not the same. Not surprisingly, these slight structural differences cause a dramatic change for how the two cannabinoid molecules interact with receptors in the human body.

THC binds to cell receptors, whereas CBD indirectly regulates the receptors and manages how they respond to other chemicals (see image below). This slight variance causes the psychoactive effect of THC while allowing CBD to help regulate pain, inflammation, mood, and stress without the psychoactive effects.

Cell receptor binding & interaction diagram for CBD and THC
Direct (THC) and indirect (CBD) binding of cannabinoids with receptors.

A different way to think about the way a chemical interacts with a receptor is a bit like a lock and key. The chemical needs to have a structure that lets it bind, or connect, in order to activate a receptor. If the chemical structure is slightly different it won’t have an impact on the receptor. So, the tiny differences in a chemical structure are like the tiny differences in a key. If it doesn’t match up perfectly, the key won’t work. THC activates the receptor in the body, whereas CBD regulates how the receptors interact with other chemicals.

CBD is dominant in Hemp – THC is dominant other plant strains

While CBD and THC can both be found in multiple strains of plants, their chemical ratios vary highly from one plant to the other. The main differentiator is the ratio of THC in the plants.

High THC plants that are specifically grown for recreational use tend to have significantly higher levels of THC because of the desire for its psychoactive effects.

  • For hemp plants, CBD is present in large amounts, up to 40%, and has less than 0.3% THC.
  • For high THC strains of plants, THC is present in large amounts, a minimum of 0.3% and up to 35% – with has far less CBD.

Legal Status

While some states have taken the full legalization path, most states still have strict laws surrounding high-THC plant use and possession. In fact, high THC plants remain a Schedule 1 controlled substance² according to federal law and are considered to have a high potential for abuse, due to THC.

Hemp and its byproducts (including CBD) enjoy a much more relaxed legal status. According to the 2018 Farm Bill³, as long as the plant has less than 0.3% THC it is considered a legal agricultural product. This means that it is legal to own and use CBD products made from hemp anywhere in the United States.

It is essential to reinforce that only products containing hemp-derived CBD are legal in the US on the federal level. If the CBD is derived from a plant with greater than 0.3% THC, it is considered an illegal controlled substance.

There are 85+ cannabinoids

THC and CBD are the highest concentrated cannabinoids with the most testing and research. But there are 80+ additional cannabinoids (depending on how the scientific source classifies the chemicals). When buying a CBD product you can either get CBD isolate or a full spectrum CBD which includes some of the other natural cannabinoids from the whole plant. Some other cannabinoids worth noting as topics of future research include:

  • Cannabidiolic Acid (CBDA)
  • Cannabinol (CBN)
  • Cannabigerol (CBG)
  • Tetrahydrocannabivarin (THCV)
Benefits of full spectrum CBD
Written by:

Alex Zorniger

Alex is an employee at Daddy Burt Hemp Co. He studied nutrition, the environment, and entrepreneurship at Tufts University before joining the Daddy Burt team as the director of business development. While working at Daddy Burt Hemp Co. Alex is also pursuing his MBA at the Fisher School of Business (Ohio State University). Alex has a passion for helping people learn about the constantly evolving Hemp industry.Alex has been featured in articles published on Forbes.com and the Cannabis Business Times.

Reviewed by:

Bob Estes

Bob is the founder and CEO of Daddy Burt Hemp Co. Bob has quickly become an authority and expert in the hemp & CBD industry. He originally developed an interest in science and engineering and received a degree in Industrial Engineering, which led him to a career in the nation’s space program. Bob worked for several aerospace companies supporting the space launch for NASA and the Department of Defense. Since Hemp farming has been revitalized in America over the last decade, his family legacy has called to him. Daddy Burt Hemp Co. is the rekindling of Bob's family's hemp farming legacy, dating back to the early 1800s.Bob has been profiled by Smiley Pete Publishing and has been featured in articles about CBD/Hemp on Forbes.com, Kentucky.com, MiamiHerald.com, NewsObserver.com and many more.

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